Description

3-Chloro-2-Fluorobenzenesulfonyl Chloride is a high-purity, multi-functional chemical intermediate essential for advanced synthesis. This compound is valued for its dual reactive sites, enabling its use as a key building block in the creation of complex, high-value molecules. It is primarily sought after by research and development teams and process chemists in the pharmaceutical and agrochemical industries for constructing novel sulfonamides and other active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, leveraging the sulfonyl chloride moiety for potent biological activity.
• Material Science Research: Serves as a precursor for functionalized polymers and specialty chemicals where the introduction of sulfonyl groups modifies material properties.
• Chemical Derivatization: Employed in analytical chemistry and proteomics for labeling and modifying biomolecules to study structure and function.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.

Basic Information

Product Name	3-Chloro-2-Fluorobenzenesulfonyl Chloride
CAS No.	351003-48-0
Molecular Formula	C6H3Cl2FO2S
Molecular Weight	229.05 g/mol
Synonyms	2-Fluoro-3-chlorobenzenesulfonyl chloride; 3-Chloro-2-fluorobenzene-1-sulfonyl chloride; 1-Chloro-2-fluoro-3-(chlorosulfonyl)benzene; Benzenesulfonyl chloride, 3-chloro-2-fluoro-; 3-Chloro-2-fluorophenylsulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-2-Fluorobenzenesulfonyl Chloride is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.