Description

4-(Difluoromethoxy)Benzenesulfonyl Chloride is a specialized organosulfur compound featuring a difluoromethoxy-substituted benzene ring. This high-purity intermediate is critical for introducing the sulfonyl chloride functional group into target molecules, enabling precise chemical synthesis. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for sulfonamide-based drugs.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides that require the sulfonyl moiety for bioactivity.
• Material Science Research: Serves as a precursor for creating specialized polymers and advanced materials with specific surface properties.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis: An essential reagent for contract research and manufacturing organizations (CROs/CMOs) performing bespoke chemical synthesis for clients.

Basic Information

Product Name	4-(Difluoromethoxy)Benzenesulfonyl Chloride
CAS No.	351003-34-4
Molecular Formula	C7H5ClF2O3S
Molecular Weight	242.63 g/mol
Synonyms	p-(Difluoromethoxy)benzenesulfonyl chloride; 1-(Difluoromethoxy)-4-(chlorosulfonyl)benzene; Benzenesulfonyl chloride, 4-(difluoromethoxy)-; 4-Difluoromethoxybenzenesulfonyl chloride; α,α-Difluoro-p-methoxybenzenesulfonyl chloride
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)Benzenesulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and identity. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.