Description

4-Ethynyl-1-Fluoro-2-Methylbenzene 97 is a high-purity, multi-functional aromatic building block featuring both an ethynyl and a fluorine substituent on a methylbenzene core. This compound is essential for advanced organic synthesis, particularly in the development of pharmaceuticals, agrochemicals, and specialty materials where its unique reactivity profile enables precise molecular construction. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex drug candidates, especially in kinase inhibitor and oncology research.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: Employed in academic and industrial labs for palladium-catalyzed cross-coupling reactions (e.g., Sonogashira, Heck) and click chemistry.
• Fluorine Chemistry Studies: Acts as a model compound for studying the effects of fluorine substitution on aromatic systems and reaction pathways.
• Ligand Synthesis: Used to prepare advanced ligands for catalysis, where the ethynyl group allows for modular attachment to various scaffolds.

Basic Information

Item	Detail
Product Name	4-Ethynyl-1-Fluoro-2-Methylbenzene 97
CAS No.	351002-93-2
Molecular Formula	C9H7F
Molecular Weight	134.15 g/mol
Synonyms	1-Ethynyl-4-fluoro-2-methylbenzene; 2-Fluoro-5-ethynyltoluene; 4-Fluoro-2-methylphenylacetylene; 2-Methyl-4-fluorophenylacetylene; 5-Ethynyl-2-fluorotoluene; 4-Ethynyl-2-fluorotoluene; 2-Fluoro-α-methylbenzeneacetylene
EINECS	Contact for details

Quality Control

Our 4-Ethynyl-1-Fluoro-2-Methylbenzene 97 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure the minimum purity of 97% and to control key impurities. Certificates of Analysis (COA) with full chromatographic data are provided with every shipment to guarantee traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is easily oxidized (store under inert atmosphere) and is compatible with strong acid/organic solvent. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.