Description

Kynurenic-3,5,6,7,8-D5 Acid CAS NO 350820-13-2 is a high-purity, deuterium-labeled internal standard critical for advanced analytical quantification. This stable isotope-labeled compound is essential for ensuring accuracy and reliability in sensitive mass spectrometry-based analyses. It is primarily utilized by research institutions, pharmaceutical developers, and CROs engaged in metabolomics, neurochemical research, and drug metabolism and pharmacokinetics (DMPK) studies.

Application

• Quantitative Mass Spectrometry: Serves as a critical internal standard for the precise LC-MS/MS and GC-MS quantification of endogenous kynurenic acid in complex biological matrices.
• Biomedical & Neurochemical Research: Enables accurate tracing and measurement in studies investigating the kynurenine pathway, neuroinflammation, and neurological disorders.
• Drug Discovery & Development: Used in DMPK studies to monitor the pharmacokinetic profile of drug candidates affecting tryptophan metabolism.
• Metabolomics & Biomarker Discovery: Provides a stable isotope reference for high-throughput profiling of metabolic changes in disease states.
• Clinical Diagnostics Development: Supports the development and validation of robust clinical assays for metabolic biomarkers.
• Quality Control & Method Validation: Essential for GLP/GMP-compliant analytical method development, validation, and routine quality control in pharmaceutical analysis.

Basic Information

Product Name	Kynurenic-3,5,6,7,8-D5 Acid
CAS No.	350820-13-2
Molecular Formula	C10D5H2NO3
Molecular Weight	194.18 g/mol (for D5 labeled form)
Synonyms	Kynurenic Acid-d5; 4-Hydroxyquinoline-2-carboxylic-3,5,6,7,8-d5 Acid; 2-Carboxy-4-hydroxyquinoline-d5; Kynurenic Acid (3,5,6,7,8-D5); [3,5,6,7,8-D5]Kynurenic Acid; Deuterated Kynurenic Acid Internal Standard; Kynurenic Acid (D5, 98%)
EINECS	Contact for details

Quality Control

Every batch of Kynurenic-3,5,6,7,8-D5 Acid is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity (typically ≥98% by HPLC and ≥98 atom % D), verified by advanced analytical techniques including NMR (1H, 13C), Mass Spectrometry, and HPLC. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment to ensure traceability and compliance with your research or quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0%
Chemical Purity (by HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.