Description

(1R,2S)-(-)-Ephedrine-Gamma,Gamma,γ-D3 Hcl CAS NO 350820-07-4 is a high-purity, isotopically labeled derivative of the classic sympathomimetic amine, ephedrine, where three hydrogen atoms are replaced with deuterium at the gamma position. This deuteration is critical for enhancing analytical precision, serving as a stable internal standard in quantitative mass spectrometry and metabolic studies. It is an essential tool for pharmaceutical R&D, forensic toxicology, and clinical research laboratories requiring definitive quantification of ephedrine and its metabolites.

Application

• Internal Standard for LC-MS/MS: Primary use as a deuterated internal standard for the accurate quantification of ephedrine and pseudoephedrine in bioanalytical methods, ensuring data reliability for pharmacokinetic and bioequivalence studies.
• Metabolic Pathway Research: Employed in tracer studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of ephedrine alkaloids in both preclinical and clinical settings.
• Forensic and Doping Control Analysis: Critical reference material for confirmatory testing in forensic toxicology and anti-doping laboratories to differentiate between endogenous and exogenous sources of stimulants.
• Pharmaceutical Quality Control: Used in the development and validation of analytical methods for the assay and impurity profiling of ephedrine-containing pharmaceutical formulations.
• Stable Isotope Labeled Compound Synthesis: Serves as a key synthetic intermediate or precursor for preparing more complex deuterated molecules for advanced research applications.

Basic Information

Product Name	(1R,2S)-(-)-Ephedrine-Gamma,Gamma,γ-D3 Hydrochloride
CAS No.	350820-07-4
Molecular Formula	C10H12D3ClNO
Molecular Weight	203.72 g/mol
Synonyms	(-)-Ephedrine-d3 hydrochloride; (1R,2S)-(-)-Ephedrine-γ,γ,γ-d3 HCl; L-Ephedrine-d3 hydrochloride; [2S-(1R*,2S*)]-α-[1-(Methylamino)ethyl]benzenemethanol-d3 hydrochloride; 1R,2S-(-)-Ephedrine-GGG-d3 HCl; Deuterated Ephedrine HCl; Ephedrine-d3 (hydrochloride salt); Stable Isotope Labeled Ephedrine HCl
EINECS	Contact for details

Quality Control

Every batch of (1R,2S)-(-)-Ephedrine-Gamma,Gamma,γ-D3 HCl is manufactured and analyzed under strict quality systems to ensure the highest standards of identity, purity, and isotopic enrichment. We provide comprehensive Certificates of Analysis (COA) that include data for assay (by HPLC), chiral purity, chemical purity, isotopic purity (D-enrichment), residual solvents, and specific identification tests. Our quality commitment supports compliance needs for GLP and GMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0% (anhydrous basis)
Chiral Purity (HPLC)	≥99.0% (1R,2S enantiomer)
Isotopic Purity (MS)	≥98 atom % D (at gamma position)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.