Description

17Beta-Dihydroequilin-2,4,16,16-D4 is a high-purity, deuterium-labeled analog of a key equine estrogen metabolite. This compound is specifically engineered for use as an internal standard in advanced analytical chemistry, providing superior accuracy and reliability in quantitative mass spectrometry. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, clinical research, and forensic toxicology sectors who require precise measurement of estrogenic compounds.

Application

• Internal Standard for LC-MS/MS: Primary application as a deuterated internal standard for the precise quantification of endogenous estrogens and related metabolites in complex biological matrices.
• Pharmaceutical R&D: Used in the development and validation of bioanalytical methods for pharmacokinetic and pharmacodynamic studies of hormone-based therapies.
• Clinical Research: Enables accurate measurement of estrogen levels in serum, plasma, and urine for endocrine disorder studies and hormone replacement therapy monitoring.
• Forensic & Doping Control: Critical for confirmatory testing in anti-doping laboratories to detect the misuse of exogenous estrogens in equine and human sports.
• Metabolomics & Biomarker Discovery: Facilitates targeted metabolomic profiling to identify and validate estrogen-related biomarkers for various disease states.
• Reference Standard: Serves as a certified reference material (CRM) for instrument calibration and method qualification to ensure regulatory compliance (e.g., FDA, EMA).

Basic Information

Product Name	17Beta-Dihydroequilin-2,4,16,16-D4
CAS No.	350819-99-7
Molecular Formula	C18H18D4O2
Molecular Weight	274.39 g/mol (for deuterated form)
Synonyms	17β-Dihydroequilin-2,4,16,16-d4; (13S,17β)-13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol-2,4,16,16-d4; Equilin-d4 metabolite; Deuterated 17β-dihydroequilin; 2,4,16,16-Tetradeutero-17β-dihydroequilin; 17β-Estradiol-2,4,16,16-d4 analog (equine series); Deuterated internal standard for equine estrogens.
EINECS	Contact for details

Quality Control

Every batch of 17Beta-Dihydroequilin-2,4,16,16-D4 is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity, confirmed by advanced techniques including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment, and solvent residue levels to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.