Description

(+/-)-Nicotine-D4 CAS NO 350818-69-8 is a deuterium-labeled isotopologue of nicotine, where four hydrogen atoms are replaced with deuterium, serving as a critical internal standard for analytical quantification. This compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, eliminating variability and providing definitive results. It is primarily required by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in pharmacokinetic studies, metabolism research, and forensic toxicology.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for nicotine and metabolite analysis.
• Pharmacokinetic and Metabolic Studies: Enables precise tracking of nicotine absorption, distribution, metabolism, and excretion (ADME) in clinical and preclinical research.
• Forensic Toxicology: Supports accurate quantification of nicotine and its derivatives in biological samples for legal and workplace testing.
• Biomarker Research: Facilitates the development and validation of assays for nicotine-related biomarkers in smoking cessation and exposure studies.
• Pharmaceutical Quality Control: Employed in the analysis of nicotine-containing products like gums, patches, and inhalers to ensure dosage accuracy.
• Environmental and Agricultural Analysis: Aids in the detection and quantification of nicotine residues in environmental samples and agricultural products.

Basic Information

Product Name	(+/-)-Nicotine-D4
CAS No.	350818-69-8
Molecular Formula	C₁₀H₁₀D₄N₂
Molecular Weight	166.26 g/mol
Synonyms	Nicotine-d4; [2H4]-Nicotine; DL-Nicotine-d4; (±)-Nicotine-3',3',5',5'-d4; 3-[(2S)-1-Methyl-2-pyrrolidinyl-d4]pyridine; 1-Methyl-2-(3-pyridyl)pyrrolidine-d4; Nicotine (tetradeuterated)
EINECS	Contact for details

Quality Control

Our (+/-)-Nicotine-D4 is manufactured under strict quality protocols to ensure high chemical purity and isotopic enrichment, which are critical for its function as an internal standard. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity, isotopic purity (atom % D), and residual solvent content. We adhere to relevant industry standards for reference materials to guarantee reliable and reproducible analytical performance.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is highly volatile and light-sensitive; prolonged exposure to light, heat, or air should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity (GC)	≥ 99.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.