Description

6'-Guanidinonaltrindole Ditrifluoroacetate is a high-purity, non-peptide chemical compound primarily utilized as a potent and selective antagonist for the delta opioid receptor (DOR). This specificity makes it a critical research tool for neuropharmacological studies and drug discovery programs targeting pain management and neurological disorders. It is essential for academic researchers, pharmaceutical R&D teams, and contract research organizations (CROs) focused on opioid receptor signaling pathways and the development of novel analgesics.

Application

• Neuroscience Research: A key pharmacological tool for studying the function and distribution of delta opioid receptors in the central nervous system.
• Drug Discovery & Development: Used in high-throughput screening (HTS) and lead optimization for developing new non-addictive pain therapeutics.
• Biochemical Assays: Employed in receptor binding studies, functional assays (e.g., GTPγS), and signal transduction research to elucidate DOR-mediated effects.
• In Vitro & Ex Vivo Studies: Facilitates the investigation of opioid receptor subtypes in cell cultures and tissue preparations.
• Reference Standard: Serves as a certified reference material for analytical method development and validation in pharmacokinetic and metabolic studies.

Basic Information

Product Name	6'-Guanidinonaltrindole Ditrifluoroacetate
CAS No.	350800-03-2
Molecular Formula	C₂₇H₃₀F₆N₆O₆
Molecular Weight	648.56 g/mol
Synonyms	6'-GNTI Ditrifluoroacetate; 6'-Guanidinonaltrindole di-TFA salt; 17-Cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6',7'-dihydro-6'-guanidinoindolo[2',3':6,7]morphinan ditrifluoroacetate; 6'-GNTI; GNTI TFA salt; Delta Opioid Receptor Antagonist 6'-GNTI; Naltrexone derivative 6'-GNTI
EINECS	Contact for details

Quality Control

Our 6'-Guanidinonaltrindole Ditrifluoroacetate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for advanced research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant standards for research chemicals, ensuring reliable performance in sensitive biological assays.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and storage under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.