Description

Apratoxin A is a potent cytotoxic cyclic depsipeptide of marine origin, known for its unique mechanism of action involving the inhibition of secretory protein translocation. This compound is a valuable research-grade biochemical for investigating novel cancer pathways and cellular protein trafficking. It is primarily utilized by researchers and pharmaceutical developers in oncology, chemical biology, and drug discovery programs. The product is supplied as a high-purity reference standard under the identifier CAS NO 350791-64-9.

Application

• Biomedical Research: A critical tool for studying the Sec61 translocon complex and its role in co-translational protein translocation into the endoplasmic reticulum.
• Oncology & Cancer Biology: Used as a molecular probe to investigate novel anti-cancer mechanisms, particularly for targeting cancer cell proliferation and survival pathways dependent on secretory protein synthesis.
• Drug Discovery & Development: Serves as a lead compound or a pharmacological tool in high-throughput screening campaigns to identify new therapeutic agents for cancer and other proliferative diseases.
• Chemical Biology & Proteomics: Employed to elucidate cellular stress responses, such as the unfolded protein response (UPR), and to validate new targets in cellular signaling networks.
• Academic & Institutional Research: Used in university and research institute laboratories for fundamental studies in cell biology, biochemistry, and marine natural product chemistry.
• Reference Standard: Provides a certified analytical standard for quality control, method development, and validation in analytical laboratories.

Basic Information

Product Name	Apratoxin A
CAS No.	350791-64-9
Molecular Formula	C₄₅H₆₉N₅O₇S
Molecular Weight	824.1 g/mol
Synonyms	Apratoxin A; (3S,6S,9S,12S,18S,21S,24S,30S)-30-[(2S)-2-Hydroxy-1-oxopropyl]-6,9,12,21,24-pentaisopropyl-3-[(1R)-1-methylpropyl]-1,4,7,10,13,16,19,22,25,28-decaoxa-2,5,8,11,14,17,20,23,26,29-decaazacyclotriacontane-15,27-dione; Marine Cytotoxin Apratoxin A
EINECS	Contact for details

Quality Control

Our Apratoxin A is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC purity analysis, mass spectrometry (MS) for identity confirmation, and NMR spectroscopy. A detailed Certificate of Analysis (COA) documenting purity, identity, and other critical parameters is provided with every shipment to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider storing under an inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to theoretical [M+H]+
Purity (HPLC)	≥ 95% (Area Percent)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.