Description

6'-Desmethyl-6'-Carboxy Etoricoxib is a key pharmaceutical intermediate and metabolite of the selective COX-2 inhibitor, Etoricoxib. This compound is of significant value in analytical chemistry and drug development for method validation and pharmacokinetic studies. It is primarily required by pharmaceutical R&D laboratories, quality control (QC) departments, and contract research organizations (CROs) involved in anti-inflammatory drug development and bioanalytical testing.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of Etoricoxib and its metabolites in biological matrices.
• Metabolite Studies: Critical for conducting ADME (Absorption, Distribution, Metabolism, and Excretion) studies to understand the metabolic pathway of Etoricoxib.
• Impurity Profiling: Serves as a specified impurity standard for the quality control and stability testing of Etoricoxib active pharmaceutical ingredient (API) and finished dosage forms.
• Bioanalytical Method Development: Essential for developing and validating sensitive HPLC, LC-MS, or LC-MS/MS methods for therapeutic drug monitoring and clinical trials.
• Pharmacokinetic Research: Employed in research to investigate the clearance and exposure levels of Etoricoxib metabolites.
• Process Chemistry: Can be used as a synthetic intermediate or a marker in the optimization of Etoricoxib manufacturing processes.

Basic Information

Product Name	6'-Desmethyl-6'-Carboxy Etoricoxib
CAS No.	349536-39-6
Molecular Formula	C17H14ClN3O4S
Molecular Weight	391.83 g/mol
Synonyms	Etoricoxib Carboxylic Acid Metabolite; Etoricoxib Impurity; 5-Chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine-4-carboxylic Acid (related isomer); 6'-Carboxy Etoricoxib; Desmethyl Carboxy Etoricoxib; Etoricoxib Related Compound; COX-2 Inhibitor Metabolite; ARCOXIA Metabolite
EINECS	Contact for details

Quality Control

Our 6'-Desmethyl-6'-Carboxy Etoricoxib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR, MS) and purity determination by advanced chromatographic techniques (HPLC, LC-MS). We provide full traceability and Certificates of Analysis (COA) detailing all test results, ensuring compliance with the stringent requirements for pharmaceutical reference standards and intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0% w/w
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.