Description

Dl-Mevalonolactone-4,4,5,5,6,6,6-D7 is a high-purity, deuterium-labeled isotopologue of mevalonolactone, a key intermediate in the mevalonate pathway. This compound is essential for researchers and manufacturers requiring precise metabolic tracing and analytical standards in biochemical studies. It is primarily utilized in pharmaceutical R&D, metabolic research, and the production of stable isotope-labeled compounds for mass spectrometry and NMR analysis.

Application

• Stable Isotope-Labeled Internal Standard for accurate quantification in LC-MS and GC-MS analysis of mevalonate pathway metabolites.
• Metabolic Pathway Tracing in biochemical and pharmacological research to study cholesterol biosynthesis, isoprenoid metabolism, and drug mechanisms.
• Deuterated Reference Material for NMR spectroscopy, providing a non-interfering signal for structural elucidation and method development.
• Precursor Synthesis for the preparation of other deuterium-labeled bioactive compounds and pharmaceutical intermediates.
• Enzyme Kinetics Studies to investigate the activity of enzymes like HMG-CoA reductase without interference from endogenous substrates.

Basic Information

Product Name	Dl-Mevalonolactone-4,4,5,5,6,6,6-D7
CAS No.	347840-19-1
Molecular Formula	C6H3D7O3
Molecular Weight	137.18 g/mol (approx.)
Synonyms	3,5-Dihydroxy-3-methylpentanoic acid δ-lactone-4,4,5,5,6,6,6-d7; (±)-Mevalonolactone-d7; DL-Mevalonic acid lactone-d7; 3-Methyl-3,5-dihydroxypentanoic acid lactone-d7; R,S-Mevalonolactone-d7; Mevalolactone-d7; 5-Hydroxy-3-methylvaleric acid δ-lactone-d7; 3-Hydroxy-3-methyl-δ-valerolactone-d7
EINECS	Contact for details

Quality Control

Our Dl-Mevalonolactone-4,4,5,5,6,6,6-D7 is manufactured under strict quality systems to ensure batch-to-batch consistency and high isotopic purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity, isotopic enrichment (D-content), and specific analytical results from NMR, MS, and HPLC. We support research and commercial applications requiring reliable and traceable reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.