Description

Ferrostatin-1 (Fer-1) is a potent, selective, and cell-permeable inhibitor of ferroptosis, a form of regulated cell death driven by iron-dependent lipid peroxidation. This compound is a critical research tool for elucidating the mechanisms of ferroptosis and its role in various disease pathologies, including neurodegenerative disorders, ischemia-reperfusion injury, and certain cancers. It is essential for researchers and developers in the fields of cell biology, pharmacology, and drug discovery who require high-purity biochemicals for mechanistic studies and therapeutic target validation.

Application

• Primary research tool for studying the molecular pathways and mechanisms of ferroptosis.
• Neuroprotective agent in models of neurodegenerative diseases such as Parkinson's, Alzheimer's, and Huntington's disease.
• Cardioprotective studies for investigating and mitigating ischemia-reperfusion injury in heart and brain tissues.
• Oncology research to understand the role of ferroptosis in tumor suppression and chemotherapy resistance.
• Renal injury research, particularly in models of acute kidney injury induced by oxidative stress.
• Validation of drug targets and screening for novel therapeutic compounds that modulate ferroptosis.
• Use in in vitro cell culture experiments and in vivo animal model studies.
• Component of specialized cell culture media for maintaining sensitive cell lines prone to ferroptotic death.

Basic Information

Product Name	Ferrostatin-1 (Fer-1)
CAS No.	347174-05-4
Molecular Formula	C₁₅H₁₂N₂O₂
Molecular Weight	252.27 g/mol
Synonyms	Fer-1; Ferrostatin 1; 3-Amino-4-cyclohexylamino-benzoic acid ethyl ester; Ethyl 3-amino-4-(cyclohexylamino)benzoate; UAMC-001; Ferroptosis Inhibitor-1; 4-(Cyclohexylamino)-3-aminobenzoic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ferrostatin-1 is produced under strict quality management protocols to ensure batch-to-batch consistency and high chemical purity suitable for advanced research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation. A detailed Certificate of Analysis (COA) containing lot-specific data is provided with every shipment to support your research integrity and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, keep containers sealed under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in DMSO, Ethanol; Slightly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.