Description

(-)-Desmethyl-Rolipram CAS NO 347148-60-1 is a high-purity, enantiomerically pure derivative of the well-known phosphodiesterase 4 (PDE4) inhibitor, Rolipram. This compound is a critical reference standard and research-grade biochemical used extensively in pharmacological and neurological studies. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on developing novel therapeutics for central nervous system disorders and inflammatory diseases.

Application

• Pharmacological Research: As a key tool compound for studying PDE4 enzyme inhibition and its role in cellular signaling pathways.
• Neuroscience Studies: Investigation of potential therapeutic effects for depression, memory disorders, and neurodegenerative conditions.
• Inflammation & Immunology Research: Exploration of anti-inflammatory mechanisms in various disease models.
• Biochemical Assay Development: Used as a standard for calibrating assays and validating analytical methods (HPLC, LC-MS).
• Drug Discovery & Development: Serving as a lead compound or intermediate in the synthesis of new PDE4-targeted pharmaceutical agents.
• Academic & Clinical Research: Fundamental studies on cyclic nucleotide signaling and its physiological impacts.

Basic Information

Product Name	(-)-Desmethyl-Rolipram
CAS No.	347148-60-1
Molecular Formula	C₁₅H₁₇NO₃
Molecular Weight	259.30 g/mol
Synonyms	(-)-4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidinone; (R)-(-)-Rolipram N-Desmethyl; (R)-(-)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone; Desmethylrolipram; PDE4 Inhibitor Derivative; (R)-Rolipram Impurity; Rolipram Metabolite
EINECS	Contact for details

Quality Control

Our (-)-Desmethyl-Rolipram is manufactured under strict quality management systems to ensure high enantiomeric purity and batch-to-batch consistency. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess determination and NMR for structural confirmation. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and available upon request to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.