Description

D-Myo-Inositol-1,4,5-Triphosphate (Ammonium Salt) is a high-purity, cell-permeant derivative of the critical second messenger inositol trisphosphate (IP3). This compound is essential for studying intracellular calcium signaling pathways, a fundamental process in cell biology and physiology. It is primarily used by researchers and manufacturers in the life sciences, pharmaceutical development, and diagnostic reagent sectors to investigate cellular communication, receptor function, and drug mechanisms.

Application

• Intracellular Calcium Signaling Research: As a cell-permeant analog of IP3, it is used to directly stimulate the release of calcium from endoplasmic reticulum stores in live cells.
• Pharmaceutical Target Validation: Employed in high-throughput screening (HTS) assays to identify and characterize novel drug candidates targeting IP3 receptors (IP3R) for therapeutic areas like neurology and cardiology.
• Cell Biology & Physiology Studies: A key tool for investigating processes such as muscle contraction, neurotransmitter release, gene expression, and cell proliferation mediated by calcium signals.
• Diagnostic Reagent Component: Used in the development of specialized assay kits and reagents for measuring phospholipase C (PLC) activity or intracellular calcium flux.
• Biochemical Standard: Serves as a critical reference standard for calibrating assays, validating methods, and ensuring quality control in research and production environments.

Basic Information

Product Name	D-Myo-Inositol-1,4,5-Triphosphate (Ammonium Salt)
CAS No.	345958-55-6
Molecular Formula	C6H15O15P3 · xNH3
Molecular Weight	~486.1 (Free acid, anhydrous basis)
Synonyms	IP3 (Ammonium Salt); D-myo-Inositol 1,4,5-trisphosphate ammonium salt; Inositol 1,4,5-trisphosphate (Ammonium); 1,4,5-IP3 ammonium salt; Ins(1,4,5)P3 ammonium salt; D-myo-Inositol-1,4,5-trisphosphate triammonium salt; (1,4,5)IP3; Inositol trisphosphate ammonium salt
EINECS	Contact for details

Quality Control

Our D-Myo-Inositol-1,4,5-Triphosphate (Ammonium Salt) is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS). Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/NMR)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.