Description

Methyl Nicotinate-2,4,5,6-D4 is a deuterium-labeled isotopologue of methyl nicotinate, a compound of significant interest in analytical and research chemistry. This high-purity, stable-labeled standard is essential for ensuring accuracy and reliability in quantitative mass spectrometry and metabolic studies. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, agrochemical, and life science sectors who require precise internal standards for method development and validation.

Application

• As a stable isotope-labeled internal standard for the accurate quantification of methyl nicotinate or related metabolites in biological matrices via LC-MS/MS and GC-MS.
• In pharmacokinetic and drug metabolism studies to track the absorption, distribution, metabolism, and excretion (ADME) of nicotinate-based compounds.
• For use in analytical method development and validation in pharmaceutical quality control and forensic toxicology laboratories.
• In dermatological research as a tracer to study the penetration and mechanism of action of topical vasodilators.
• As a key reagent in synthetic organic chemistry for preparing deuterated analogs of more complex molecules for mechanistic studies.

Basic Information

Product Name	Methyl Nicotinate-2,4,5,6-D4
CAS No.	345909-99-1
Molecular Formula	C7H3D4NO2
Molecular Weight	141.17 g/mol
Synonyms	Methyl Nicotinate-d4; 3-Pyridinecarboxylic Acid, Methyl-d3 Ester-2,4,5,6-d4; Methyl 3-Pyridinecarboxylate-2,4,5,6-d4; Deuterated Methyl Nicotinate; Nicotinic Acid Methyl Ester-d4; Methyl Niacinate-d4; 3-Carbomethoxypyridine-d4
EINECS	Contact for details

Quality Control

Our Methyl Nicotinate-2,4,5,6-D4 is manufactured under strict quality control protocols to ensure high chemical purity and isotopic enrichment. Each batch is analyzed using advanced spectroscopic and chromatographic techniques, including NMR and HPLC-MS, to confirm identity, chemical purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.