Description

Sf1670 (Pteninhibitor) is a potent and selective small molecule inhibitor of the PTEN (Phosphatase and Tensin Homolog) protein, a critical tumor suppressor. This compound is a vital research tool for studying cellular signaling pathways, particularly the PI3K/AKT/mTOR axis, which is central to cell growth, proliferation, and survival. It is primarily used by researchers and scientists in the fields of oncology, molecular biology, and biochemistry for target validation, mechanism-of-action studies, and preclinical drug discovery.

Application

• Biomedical Research: Fundamental research tool for investigating the role of PTEN in cellular signaling, apoptosis, and metabolism.
• Oncology Studies: Used in cancer research to model PTEN-deficient tumors and explore downstream therapeutic targets in the PI3K pathway.
• Drug Discovery & Development: Serves as a pharmacological probe for target validation and screening in preclinical stages of anticancer drug development.
• Cell Biology & Signal Transduction: Enables the study of cross-talk between PTEN and other critical pathways affecting cell cycle and growth.
• Academic & Institutional Research: Essential for universities and research institutes conducting studies on tumor suppression and cellular regulation.

Basic Information

Product Name	Sf1670 (Pteninhibitor)
CAS No.	345630-40-2
Molecular Formula	C₁₉H₁₈N₄O₂
Molecular Weight	334.37 g/mol
Synonyms	SF1670; PTEN Inhibitor; 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile, 2-[(1E)-2-(4-fluorophenyl)ethenyl]-4,6-dimethyl-; SF-1670; PTEN inhibitor SF1670; 2-[(E)-2-(4-Fluorophenyl)vinyl]-4,6-dimethyl-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile; 4,6-Dimethyl-2-[(E)-2-(4-fluorophenyl)vinyl]-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile
EINECS	Contact for details

Quality Control

Our Sf1670 (Pteninhibitor) is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.