Description

Leukadherin 1 CAS NO 344897-95-6 is a potent and selective small molecule inhibitor of the leukocyte function-associated antigen-1 (LFA-1) integrin. This compound is crucial for researchers and developers targeting inflammatory and autoimmune pathways, as it modulates critical cell adhesion processes. It is primarily utilized in pharmaceutical R&D for investigating novel therapeutics in areas such as transplant rejection, psoriasis, and multiple sclerosis.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active agent in the discovery of anti-inflammatory and immunomodulatory drugs.
• Autoimmune Disease Studies: Used in in vitro and in vivo models to investigate conditions like rheumatoid arthritis, psoriasis, and inflammatory bowel disease (IBD).
• Transplant Immunology: Explored for its potential to prevent organ transplant rejection by inhibiting leukocyte adhesion and migration.
• Cell Adhesion & Signaling Pathways: A vital tool for basic research into integrin-mediated cell-cell interactions, signal transduction, and immune cell activation.
• Biomarker & Diagnostic Development: May be employed in assays to study LFA-1 expression and function in various disease states.
• Preclinical Formulation Development: Used in stability studies and the development of suitable dosage forms for potential therapeutic candidates.

Basic Information

Product Name	Leukadherin 1
CAS No.	344897-95-6
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	(S)-5-[(4-Fluorophenyl)methyl]-2-(4-pyridinyl)-4-thiazolecarboxylic acid; LFA-1 inhibitor Leukadherin-1; BMS-688521; (4S)-5-[(4-Fluorophenyl)methyl]-2-(4-pyridin-4-yl)-1,3-thiazole-4-carboxylic acid; (S)-5-(4-Fluorobenzyl)-2-(pyridin-4-yl)thiazole-4-carboxylic acid; Leukadherin-1; LFA-1 Antagonist
EINECS	Contact for details

Quality Control

Our Leukadherin 1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research-grade standards and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.