Description

Pj-34 CAS NO 344458-15-7 is a high-purity, small-molecule chemical compound widely recognized as a potent and selective inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1). This compound matters for researchers and developers as it provides a critical tool for investigating cellular mechanisms related to DNA repair, apoptosis, and inflammation. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on oncology, neurology, and cardiovascular disease research.

Application

• Biomedical Research: A key pharmacological tool for studying the role of PARP-1 in DNA damage response, cell death pathways (parthanatos), and genomic stability.
• Drug Discovery & Development: Used as a reference standard and lead compound in the development of novel PARP inhibitors for cancer therapy and other diseases.
• Oncology Studies: Employed in in vitro and in vivo models to investigate chemopotentiation and radiosensitization effects in various cancer cell lines.
• Neuroprotection Research: Applied in experimental models of stroke, traumatic brain injury, and neurodegenerative disorders to explore PARP-1's role in neuronal cell death.
• Cardiovascular Research: Utilized to study myocardial reperfusion injury, heart failure, and other conditions where PARP overactivation is implicated.
• Inflammation & Immunology: Investigated for its effects on inflammatory signaling pathways and immune cell function.

Basic Information

Product Name	Pj-34
CAS No.	344458-15-7
Molecular Formula	C₁₇H₁₄N₂O₃
Molecular Weight	294.31 g/mol
Synonyms	PJ34; N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride; Phenanthridinone PJ34; PARP Inhibitor PJ34; PJ-34 HCl; 2-(Dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide hydrochloride
EINECS	Contact for details

Quality Control

Our Pj-34 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥98%), and specific impurities is provided with every shipment to ensure reliable and reproducible results for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccant use. Keep the container tightly sealed when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.