Description

15-Epi-Treprostinil is a synthetic prostacyclin analog and a stereoisomer of the active pharmaceutical ingredient Treprostinil. This compound is of significant interest in pharmaceutical research and development, particularly for its potential as a reference standard and an intermediate in the synthesis of novel therapeutic agents. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in cardiovascular and pulmonary drug discovery programs.

Application

• Pharmaceutical reference standard for analytical method development and validation.
• Key intermediate in the research-scale synthesis of novel prostacyclin receptor agonists.
• Biochemical tool for studying prostacyclin (PGI2) signaling pathways and receptor pharmacology.
• Impurity standard for quality control and stability testing of Treprostinil Active Pharmaceutical Ingredient (API) and related drug products.
• Starting material for the preparation of deuterated or other isotopically labeled analogs for pharmacokinetic studies.
• Preclinical research compound for investigating structure-activity relationships (SAR) within the prostacyclin analog class.

Basic Information

Product Name	15-Epi-Treprostinil
CAS No.	343247-13-2
Molecular Formula	C23H34O5
Molecular Weight	390.51 g/mol
Synonyms	15-epi-Treprostinil; (1R,2R,3aS,9aS)-[[2,3,3a,4,9,9a-Hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]acetic Acid; 15-epi-Treprostinil Sodium; UNII-1Q3P8918VU; 15-Epi-Treprostinil (free acid); Prostacyclin analog 15-epi isomer; 15-epi-Treprostinil (15R-epimer)
EINECS	Contact for details

Quality Control

Our 15-Epi-Treprostinil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR, MS), and residual solvent analysis to ensure it meets high-purity standards suitable for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all test results against established specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, desiccate to protect against moisture. Allow the sealed container to reach room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.