Description

Ent-Amyloid β-Protein (1-42) is a synthetic peptide enantiomer of the amyloid-beta protein fragment, a key molecule in neurological research. This compound is crucial for studying the structural and pathological mechanisms of Alzheimer's disease without the confounding effects of natural chirality. It is an essential research-grade biochemical for academic institutions, pharmaceutical R&D departments, and biotechnology companies focused on neurodegenerative disorders and peptide therapeutics.

Application

• Neuroscience Research: Primary tool for investigating the aggregation kinetics, toxicity, and structural biology of amyloid-beta peptides in Alzheimer's disease models.
• Drug Discovery & Screening: Used as a target in high-throughput assays to identify and validate potential therapeutic inhibitors of amyloid fibril formation.
• Biophysical Studies: Enables comparative studies on the chirality-dependent behavior of amyloid-beta, using techniques like circular dichroism (CD) and nuclear magnetic resonance (NMR).
• Antibody & Diagnostic Development: Serves as a critical antigen for characterizing the specificity of antibodies and developing diagnostic assays for amyloid-related pathologies.
• Control Substance: Acts as a non-natural stereoisomer control in experiments to distinguish chiral-specific interactions from non-specific binding events.
• Teaching & Reference Standard: Used in advanced academic settings to demonstrate principles of protein misfolding, peptide synthesis, and neurochemistry.

Basic Information

Product Name	Ent-Amyloid β-Protein (1-42)
CAS No.	342896-25-7
Molecular Formula	C203H311N55O60S
Molecular Weight	4514.0 g/mol (approximately)
Synonyms	ent-Aβ(1-42); ent-Amyloid β-Protein (1-42); D-Amyloid β-Protein (1-42) (enantiomer); Amyloid β-Peptide (1-42) enantiomer; Aβ42 enantiomer; ent-Aβ42; (all-D)-Aβ(1-42); Amyloid β (1-42) (all-D-isomer)
EINECS	Contact for details

Quality Control

Our Ent-Amyloid β-Protein (1-42) is manufactured under strict quality systems suitable for research applications. Each batch is characterized to ensure high purity and structural integrity, with analysis typically including reversed-phase HPLC, mass spectrometry (MS), and amino acid analysis. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are provided to ensure traceability and reproducibility for your critical research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Molecular Weight	4514.0 ± 2.0 Da (by MS)
Solubility	Soluble in dilute ammonium hydroxide or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.