Description

1-tert-Butyl-3,5-Difluorobenzene is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. Its molecular structure, featuring a sterically hindered tert-butyl group and two strategically placed fluorine atoms, makes it a valuable precursor for creating complex molecules with tailored properties. This compound is primarily sought after by research institutions and industrial R&D departments in the pharmaceutical and agrochemical sectors for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the difluorobenzene moiety can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a backbone for constructing sophisticated ligands in transition metal catalysis and organocatalysis, enabling more efficient and selective chemical transformations.
• Material Science Research: Employed in the development of specialty polymers, liquid crystals, and electronic materials, where fluorine incorporation can modify thermal stability, solubility, and dielectric properties.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	1-tert-Butyl-3,5-Difluorobenzene
CAS No.	342822-68-8
Molecular Formula	C10H12F2
Molecular Weight	170.20 g/mol
Synonyms	3,5-Difluoro-1-tert-butylbenzene; 1-(tert-Butyl)-3,5-difluorobenzene; tert-Butyl-3,5-difluorobenzene; 3,5-Difluorophenyl-tert-butane; (3,5-Difluorophenyl)(1,1-dimethylethyl); Benzene, 1-(1,1-dimethylethyl)-3,5-difluoro-
EINECS	Contact for details

Quality Control

Every batch of 1-tert-Butyl-3,5-Difluorobenzene is manufactured and tested under a strict quality management system. We employ advanced analytical techniques including GC, HPLC, and NMR to ensure identity, purity, and consistency meet the exacting standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee full traceability and support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.