Description

Efalizumab is a recombinant humanized monoclonal IgG1 antibody designed to target the CD11a subunit of lymphocyte function-associated antigen-1 (LFA-1). This targeted mechanism of action makes it a critical biological agent for modulating specific immune responses. It is primarily utilized in advanced pharmaceutical research and development for investigating novel therapeutic pathways. Efalizumab CAS NO 339155-58-7 represents a high-purity reference standard essential for preclinical studies and analytical method development.

Application

• Pharmaceutical Reference Standard: Serves as a primary standard for quality control and assay calibration in biopharmaceutical manufacturing.
• Biomedical Research: Used in in vitro and in vivo studies to investigate T-cell adhesion, activation, and trafficking mechanisms.
• Therapeutic Development: A key material for the research and development of next-generation immunomodulatory therapies targeting autoimmune pathways.
• Diagnostic Reagent Development: Employed in the creation of immunoassays and diagnostic kits for detecting and quantifying specific immune markers.
• Academic & Institutional Research: Supports fundamental immunological research in university and institutional laboratories worldwide.

Basic Information

Product Name	Efalizumab
CAS No.	339155-58-7
Molecular Formula	C6420H9912N1720O2018S44
Molecular Weight	Approx. 148 kDa
Synonyms	Anti-Human CD11a Recombinant Antibody; Raptiva; hu1124; LFA-3-TIP; Recombinant Humanized Anti-CD11a Monoclonal Antibody; Anti-CD11a mAb; Efalizumab-rsts; Immunoglobulin G1, anti-(human antigen CD11a (integrin α-L)) (human-mouse monoclonal hu1124 gamma1-chain), disulfide with human-mouse monoclonal hu1124 κ-chain, dimer
EINECS	Contact for details

Quality Control

Our Efalizumab is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including SDS-PAGE, size-exclusion HPLC (SE-HPLC) for purity and aggregation analysis, peptide mapping, and potency assays to ensure biological activity and consistency. Certificates of Analysis (COA) detailing all release specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -70°C to -80°C to avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (SDS-PAGE)	Complies
Purity (SE-HPLC)	≥ 95.0% (Monomer)
Protein Content (UV Absorbance)	90% - 110% of label claim
Endotoxin (LAL Test)	< 1.0 EU/mg
Biological Activity (Cell-based Assay)	Complies with reference standard
Sterility (Membrane Filtration)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.