Description

Tetrahydro-2-Furanmethanesulfonyl Chloride is a specialized sulfonyl chloride derivative, a crucial building block in advanced organic synthesis. Its primary value lies in its reactivity as a sulfonylation agent, enabling the efficient introduction of the tetrahydrofuranmethanesulfonyl (THFMS) group into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), especially for sulfonamide-based drugs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides requiring specific sulfonyl group functionalities.
• Peptide Chemistry: Employed as a sulfonylating agent for protecting groups or for modifying amino acid side chains during peptide synthesis.
• Material Science: Building block for creating specialized polymers, ligands, or surface-modifying agents with unique properties.
• Chemical Biology Probes: Useful in the design and synthesis of molecular probes for studying enzyme activity or protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring the introduction of a complex sulfonate ester or sulfonamide linkage.

Basic Information

Product Name	Tetrahydro-2-Furanmethanesulfonyl Chloride
CAS No.	338453-29-5
Molecular Formula	C6H11ClO3S
Molecular Weight	198.67 g/mol
Synonyms	2-(Chlorosulfonylmethyl)tetrahydrofuran; Tetrahydrofurfurylsulfonyl Chloride; (Tetrahydro-2-furyl)methanesulfonyl Chloride; THFMS-Cl; 2-Tetrahydrofurylmethanesulfonyl Chloride; (Oxolan-2-yl)methanesulfonyl chloride; 2-(Chlorosulfonylmethyl)oxolane
EINECS	Contact for details

Quality Control

Every batch of Tetrahydro-2-Furanmethanesulfonyl Chloride is produced and tested under a strict quality management system. We ensure high purity and consistency through advanced analytical techniques including HPLC, GC, and NMR. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee it meets your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C (refrigerated) or as specified on the label. Due to its hygroscopic (moisture-sensitive) nature, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.