Description

Tetrahydropyran-4-Sulfonylchloride is a versatile and reactive sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its ability to act as a sulfonylation reagent, enabling the efficient introduction of the tetrahydropyran-4-sulfonyl moiety into target molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries, particularly for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, especially in medicinal chemistry programs targeting enzyme inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the sulfonamide group is a common pharmacophore.
• Material Science Research: Employed in the creation of specialty polymers, functionalized surfaces, and advanced organic frameworks (MOFs/COFs).
• Chemical Biology & Proteomics: Acts as a reactive handle for bioconjugation and the development of chemical probes to study biological systems.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex organic molecules for clients.
• Academic Research: Used in university and institutional labs for methodological development in organic chemistry and exploring new synthetic pathways.

Basic Information

Product Name	Tetrahydropyran-4-Sulfonylchloride
CAS No.	338453-21-7
Molecular Formula	C5H9ClO3S
Molecular Weight	184.64 g/mol
Synonyms	4-Tetrahydropyranylsulfonyl chloride; THP-4-Sulfonyl Chloride; Tetrahydropyran-4-sulfonyl chloride; 3,4,5,6-Tetrahydro-2H-pyran-4-sulfonyl chloride; 4-Chlorosulfonyltetrahydropyran; Oxane-4-sulfonyl chloride; 4-Sulfonylchloridotetrahydropyran
EINECS	Contact for details

Quality Control

Every batch of Tetrahydropyran-4-Sulfonylchloride is produced and tested under strict quality management protocols to ensure consistency and reliability for your critical applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards and customer-specific requirements. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Solubility	Soluble in common organic solvents (DCM, THF, Acetone)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.