Description

Necrostatin-5 CAS NO 337349-54-9 is a potent and selective small-molecule inhibitor of necroptosis, a form of programmed cell death. This compound is a critical research tool for investigating cell death pathways, offering significant value in the study of inflammatory diseases, neurodegenerative disorders, and ischemic injuries. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel therapeutics targeting regulated necrosis.

Application

• Biomedical Research: A key reagent for studying the molecular mechanisms of necroptosis and its role in disease pathology.
• Drug Discovery: Used as a lead compound or pharmacological tool in high-throughput screening and target validation for anti-necroptotic therapies.
• Neurodegenerative Disease Models: Applied in cellular and animal models of Alzheimer's disease, Parkinson's disease, and ALS to assess neuroprotective effects.
• Ischemia-Reperfusion Injury Studies: Investigated in models of stroke, myocardial infarction, and organ transplantation to mitigate tissue damage.
• Inflammatory Condition Research: Utilized to explore the contribution of necroptosis to conditions like sepsis, inflammatory bowel disease, and psoriasis.
• Academic & Institutional Labs: Serves as a standard compound for teaching and advanced research in cell biology and pharmacology courses.

Basic Information

Product Name	Necrostatin-5
CAS No.	337349-54-9
Molecular Formula	C₁₄H₁₃N₃O₂
Molecular Weight	255.27 g/mol
Synonyms	Nec-5; 5-(1H-Indol-3-ylmethyl)-2-thiohydantoin; 5-(Indol-3-ylmethyl)-2-thioxoimidazolidin-4-one; 3-(4-Oxo-2-thioxoimidazolidin-5-yl)methyl-1H-indole; Necrostatin-5 (Nec-5); 1H-Indole-3-methanol, α-(4-oxo-2-thioxo-5-imidazolidinylidene)-; Necroptosis inhibitor Nec-5
EINECS	Contact for details

Quality Control

Our Necrostatin-5 is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurities is provided with every shipment to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.