Description

Ispinesib is a potent and selective small-molecule inhibitor of kinesin spindle protein (KSP/Eg5), a key mitotic motor protein essential for proper cell division. This targeted mechanism makes it a valuable research tool for studying mitotic progression and a promising candidate for the development of novel anti-cancer therapeutics. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology drug discovery and cell biology research.

Application

• Oncology Research & Drug Discovery: As a lead compound for investigating novel anti-mitotic cancer therapies targeting the KSP/Eg5 protein.
• Biochemical & Cell-Based Assays: Used in high-throughput screening (HTS) and mechanism-of-action studies to understand spindle assembly and mitotic checkpoint signaling.
• Preclinical Development: Evaluation of pharmacokinetics, pharmacodynamics, and efficacy in various in vitro and in vivo cancer models.
• Chemical Biology Studies: A critical probe for dissecting the role of kinesin motors in cell cycle regulation, apoptosis, and aneuploidy.
• Reference Standard: Serves as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	Ispinesib
CAS No.	336113-53-2
Molecular Formula	C30H32ClN5O3
Molecular Weight	546.06 g/mol
Synonyms	SB-715992; CK0238273; (S)-1-(3-Aminopropyl)-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrole-3-carboxamide; 1H-Pyrrole-3-carboxamide, 1-(3-aminopropyl)-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-methyl-5-[4-(methylsulfonyl)phenyl]-, (S)-; KSP Inhibitor SB-715992; Eg5 Inhibitor Ispinesib
EINECS	Contact for details

Quality Control

Our Ispinesib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic nature, the container should be allowed to reach room temperature before opening to minimize moisture absorption. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.