Description

4’-Raloxifene-β-D-Glucopyranoside is a glucuronide metabolite of the selective estrogen receptor modulator (SERM) raloxifene. This compound is of significant interest for its role in metabolic and pharmacokinetic studies, providing crucial insights into the biotransformation and clearance pathways of the parent drug. It is primarily utilized by pharmaceutical researchers, analytical laboratories, and contract development and manufacturing organizations (CDMOs) engaged in drug metabolism and pharmacokinetics (DMPK) research, bioanalytical method development, and the synthesis of reference standards.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for the quantitative and qualitative analysis of raloxifene and its metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK): Essential for in vitro and in vivo studies to elucidate the metabolic fate, bioavailability, and excretion profiles of raloxifene.
• Bioanalytical Method Development: Used as a standard for developing and validating sensitive HPLC-MS/MS or LC-UV methods for therapeutic drug monitoring and pharmacokinetic assays.
• Impurity Profiling: Employed in the identification and quantification of process-related impurities or degradation products in raloxifene API and finished dosage forms.
• Preclinical Research: Supports investigative studies on the pharmacological activity, toxicity, and tissue distribution of raloxifene metabolites.

Basic Information

Product Name	4’-Raloxifene-β-D-Glucopyranoside
CAS No.	334758-19-9
Molecular Formula	C32H35NO11S
Molecular Weight	641.69 g/mol
Synonyms	Raloxifene 4'-Glucuronide; Raloxifene Glucuronide; Raloxifene-4'-β-D-Glucuronide; 6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl{4-[2-(1-piperidinyl)ethoxy]phenyl}methanone 4'-β-D-Glucopyranosiduronic Acid; LY353381 Glucuronide; Keoxifene Glucuronide
EINECS	Contact for details

Quality Control

Our 4’-Raloxifene-β-D-Glucopyranoside is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all test results against established specifications to ensure reliability and traceability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.