Description

6-Raloxifene-β-D-Glucopyranoside is a glucuronide metabolite of the selective estrogen receptor modulator (SERM) raloxifene. This compound is of significant interest for its role in metabolic and pharmacokinetic studies, providing crucial insights into the biotransformation and clearance pathways of the parent drug. It is primarily utilized by pharmaceutical R&D laboratories, analytical reference standard providers, and academic research institutions focused on endocrinology, drug metabolism, and bioanalytical method development.

Application

• Pharmaceutical Reference Standard: Serves as a high-purity certified standard for the quantitative and qualitative analysis of raloxifene and its metabolites in biological matrices and pharmaceutical formulations.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a critical metabolite in studies investigating the absorption, distribution, metabolism, and excretion (ADME) profile of raloxifene.
• Bioanalytical Method Development: Essential for developing and validating sensitive HPLC, LC-MS, or LC-MS/MS methods for therapeutic drug monitoring and pharmacokinetic research.
• Biochemical Research: Employed in vitro studies to investigate the biological activity, receptor binding affinity, and downstream effects of raloxifene glucuronides.
• Impurity Profiling: Acts as a specified impurity or degradation product reference in the quality control of raloxifene active pharmaceutical ingredient (API) and finished dosage forms.

Basic Information

Product Name	6-Raloxifene-β-D-Glucopyranoside
CAS No.	334758-18-8
Molecular Formula	C33H35NO11S
Molecular Weight	653.70 g/mol
Synonyms	Raloxifene 6-β-D-Glucuronide; Raloxifene Glucuronide; Raloxifene 6-Glucuronide; 6-O-β-D-Glucopyranosylraloxifene; (6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl)(4-(2-(1-piperidinyl)ethoxy)phenyl)methanone β-D-Glucopyranosiduronic Acid; EVISTA Metabolite
EINECS	Contact for details

Quality Control

Our 6-Raloxifene-β-D-Glucopyranoside is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the stringent requirements for research and reference standard use. A detailed Certificate of Analysis (COA) containing batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.