Description

n-(2-Aminoethyl) Cyclopamine is a chemically modified derivative of the natural steroidal alkaloid cyclopamine, designed for enhanced research utility. This compound is a critical tool for the targeted inhibition of the Hedgehog (Hh) signaling pathway, a key regulator in developmental biology and oncogenesis. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in cancer research, regenerative medicine, and developmental studies.

Application

• Biochemical Research: A potent and selective small-molecule inhibitor for studying the Hedgehog signaling pathway in vitro and in vivo.
• Oncology & Cancer Research: Investigation of therapeutic strategies targeting Hh pathway-dependent cancers, such as basal cell carcinoma and medulloblastoma.
• Stem Cell & Developmental Biology: Used to manipulate cell fate and differentiation in studies of embryonic development and tissue regeneration.
• Drug Discovery & Lead Optimization: Serves as a reference compound and a chemical scaffold for the development of novel anticancer therapeutics.
• Mechanistic Studies: Elucidation of the role of Smoothened (SMO) receptor and downstream effectors in various physiological and pathological processes.

Basic Information

Product Name	n-(2-Aminoethyl) Cyclopamine
CAS No.	334616-31-8
Molecular Formula	C29H46N2O2
Molecular Weight	454.70 g/mol
Synonyms	11-Deoxojervine-3-ethylamine; Cyclopamine ethylamine derivative; N-(2-Aminoethyl)-11-deoxojervine; KAAD-Cyclopamine analog; Hedgehog pathway inhibitor derivative; SMO inhibitor intermediate; 3β-(2-Aminoethoxy)-11-deoxojervine
EINECS	Contact for details

Quality Control

Our n-(2-Aminoethyl) Cyclopamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment to ensure traceability, purity, and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.