Description

1-Methoxymethoxy-3-Trifluoromethyl-Benzene is a high-purity, specialized aromatic building block featuring a methoxymethoxy protecting group and a trifluoromethyl substituent. This compound is valued for its role as a versatile intermediate in advanced organic synthesis, particularly where controlled reactivity and fluorine incorporation are required. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially those targeting CNS disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic electronic materials for displays and lighting.
• Advanced Polymer Chemistry: Employed as a monomer or modifier to introduce fluorine atoms into polymer backbones, improving chemical resistance and surface properties.
• Protecting Group Chemistry: The methoxymethoxy (MOM) group is utilized for the temporary protection of hydroxyl functionalities during complex multi-step syntheses.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions like Suzuki-Miyaura or Buchwald-Hartwig aminations for constructing biaryl systems.

Basic Information

Product Name	1-Methoxymethoxy-3-Trifluoromethyl-Benzene
CAS No.	334018-79-0
Molecular Formula	C10H11F3O2
Molecular Weight	220.19 g/mol
Synonyms	3-(Trifluoromethyl)phenyl methoxymethyl ether; (3-Trifluoromethylphenyl)methoxymethyl ether; 1-Methoxy-1-(3-trifluoromethylphenoxy)methane; 3-(Methoxymethoxy)benzotrifluoride; m-(Trifluoromethyl)phenyl MOM ether; MOM ether of 3-(Trifluoromethyl)phenol; α-Methoxy-α-(3-trifluoromethylphenoxy)methane
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for high-purity intermediates. Every batch is analyzed via GC, HPLC, and NMR to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) are available upon request, detailing all relevant specifications. We adhere to a quality management system to ensure batch-to-batch consistency and traceability for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is sensitive to strong alkalis and fluorides; store separately from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Total impurities ≤ 2.0%
Density (at 20°C)	~1.25 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.