Description

Cobiprostone CAS NO 333963-42-1 is a synthetic prostaglandin E1 (PGE1) analogue, specifically a bicyclic benzofuran derivative, designed for enhanced stability and targeted biological activity. This compound is of significant interest in pharmaceutical research and development due to its potent cytoprotective and anti-inflammatory properties. It is primarily utilized by pharmaceutical companies and research institutions engaged in developing novel therapeutics for gastrointestinal disorders, mucosal protection, and inflammatory conditions.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced investigational drugs targeting prostaglandin receptors.
• Gastrointestinal Research: Used in preclinical studies for the development of treatments for ulcers, gastritis, and other mucosal injuries.
• Cytoprotective Agent Development: Investigated for its ability to protect cells and tissues from damage caused by stress, toxins, or ischemia.
• Inflammation Modulation: Applied in research focused on modulating inflammatory pathways for conditions like inflammatory bowel disease (IBD).
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis (HPLC, LC-MS).

Basic Information

Product Name	Cobiprostone
CAS No.	333963-42-1
Molecular Formula	C23H30O5
Molecular Weight	386.48 g/mol
Synonyms	SPI-8811; Cobiprostone; 7-[(1R,2R,3R)-3-Hydroxy-2-[(1E,3S)-3-hydroxy-4-phenoxy-1-buten-1-yl]-5-oxocyclopentyl]-4,5-heptadienoic acid; (11α,13E,15S)-11,15-Dihydroxy-9-oxo-16-phenoxy-17,18,19,20-tetranor-5-thiaprosta-4,13-dien-1-oic acid S,S-Dioxide; Prostaglandin E1 analogue; Bicyclic benzofuran prostaglandin.
EINECS	Contact for details

Quality Control

Our Cobiprostone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) detailing specifications such as assay, related substances, and residual solvents are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature of 15-25°C (59-77°F) to minimize oxidation and ensure stability. The container should be kept in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.