Description

Tesetaxel is a potent semi-synthetic taxane derivative developed as a next-generation chemotherapeutic agent. This compound is significant for its enhanced activity and potential to overcome resistance mechanisms associated with earlier taxane drugs like paclitaxel and docetaxel. It is primarily required by pharmaceutical R&D laboratories and manufacturers engaged in the development of novel oncology therapeutics.

Application

• Oncology Research & Development: As a key active pharmaceutical ingredient (API) in preclinical and clinical studies for various cancers.
• Anticancer Drug Formulation: Used in the development of injectable formulations and novel drug delivery systems such as nanoparticles or liposomes.
• Mechanistic Studies: Employed in biochemical research to study microtubule stabilization, cell cycle arrest, and apoptosis induction.
• Combinatorial Therapy Development: Investigated in combination with other chemotherapeutic agents or targeted therapies to enhance efficacy and reduce side effects.
• Reference Standard: Serves as a high-purity analytical standard for quality control and pharmacokinetic studies in pharmaceutical manufacturing.

Basic Information

Product Name	Tesetaxel
CAS No.	333754-36-2
Molecular Formula	C₄₅H₅₇NO₁₄
Molecular Weight	836.0 g/mol
Synonyms	DJ-927; TPI-287; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecah-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl (2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate; 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, taxane derivative
EINECS	Contact for details

Quality Control

Our Tesetaxel is manufactured under strict quality management systems to ensure it meets the high standards required for pharmaceutical research and development. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.