Description

7-(3-(4-Chlorophenoxy)-2-Hydroxypropyl)-3-Methyl-8-(Pyrrolidin-1-Yl)-3,7-Dihydro-1H-Purine-2,6-Dione is a high-purity, advanced pharmaceutical intermediate of significant commercial interest. This compound is valued for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting specific receptor pathways. It is primarily sought by research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel therapeutic agents, particularly in central nervous system (CNS) and cardiovascular research.
• Biochemical Research: Used as a reference standard or a ligand in pharmacological studies to investigate receptor binding and enzyme inhibition.
• Drug Discovery & Development: Serves as a core scaffold for medicinal chemistry efforts aimed at creating new chemical entities with optimized biological activity.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of clinical trial materials and commercial APIs.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis and medicinal chemistry.

Basic Information

Item	Details
Product Name	7-(3-(4-Chlorophenoxy)-2-Hydroxypropyl)-3-Methyl-8-(Pyrrolidin-1-Yl)-3,7-Dihydro-1H-Purine-2,6-Dione
CAS No.	333752-15-1
Molecular Formula	C19H22ClN5O4
Molecular Weight	419.86 g/mol
Synonyms	7-[3-(4-Chlorophenoxy)-2-hydroxypropyl]-3-methyl-8-(pyrrolidin-1-yl)-3,7-dihydro-1H-purine-2,6-dione; 7-(3-(4-Chlorophenoxy)-2-hydroxypropyl)-3-methyl-8-(pyrrolidin-1-yl)-3,7-dihydro-1H-purine-2,6-dione; 333752-15-1; 8-(1-Pyrrolidinyl)-3-methyl-7-[3-(4-chlorophenoxy)-2-hydroxypropyl]-3,7-dihydro-1H-purine-2,6-dione; 1H-Purine-2,6-dione, 3,7-dihydro-7-[3-(4-chlorophenoxy)-2-hydroxypropyl]-3-methyl-8-(1-pyrrolidinyl)-
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support development and commercial projects with material suitable for research use and can supply grades manufactured under GMP-like conditions for pre-clinical and clinical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.