Description

Zm 447439 is a potent and selective small-molecule inhibitor of Aurora kinases, key regulators of cell division. This compound is a critical research tool for studying mitotic progression, chromosomal instability, and cancer biology. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology drug discovery and cellular signaling pathways. Zm 447439 CAS NO 331771-20-1 provides a reliable reference standard for assay development and mechanistic studies.

Application

• Biochemical Research: Used as a selective inhibitor to study the function and inhibition mechanisms of Aurora A and Aurora B kinases in in vitro assays.
• Cancer Research: A vital tool for investigating the role of Aurora kinases in tumor cell proliferation, apoptosis, and aneuploidy.
• Drug Discovery & Development: Serves as a pharmacological probe and lead compound in the screening and development of novel anti-cancer therapeutics.
• Cell Biology Studies: Employed to disrupt mitotic processes, enabling the study of spindle assembly checkpoint, cytokinesis, and chromosome segregation.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	Zm 447439
CAS No.	331771-20-1
Molecular Formula	C₂₁H₂₂FN₃O₃
Molecular Weight	383.42 g/mol
Synonyms	ZM-447439; ZM447439; 4-(4'-Benzamidoanilino)-6,7-dimethoxyquinazoline; N-[4-[6,7-Dimethoxy-4-quinazolinyl]amino]phenyl]benzamide; Aurora Kinase Inhibitor I; Aurora Kinase Inhibitor ZM 447439
EINECS	Contact for details

Quality Control

Our Zm 447439 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.