Description

Aurora Kinase Inhibitor II is a potent and selective small molecule inhibitor of Aurora kinases, key regulators of cell division. This compound is a critical research tool for investigating mitotic progression, chromosomal instability, and oncogenesis in cellular and animal models. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology and cell biology. The product is supplied under the CAS number 331770-21-9 to ensure precise identification and sourcing.

Application

• Biochemical Research: Used as a selective inhibitor to study the specific roles of Aurora kinases A and B in mitotic spindle assembly, chromosome alignment, and cytokinesis.
• Oncology Drug Discovery: Serves as a reference compound and a starting point for the development of novel anti-cancer therapeutics targeting aberrant cell proliferation.
• Cell Cycle Analysis: Employed in functional assays to induce mitotic arrest and polyploidy, enabling the study of cell cycle checkpoints and mechanisms of aneuploidy.
• Preclinical Studies: Utilized in in vitro and in vivo models to evaluate the efficacy and pharmacodynamics of Aurora kinase inhibition on tumor growth.
• Mechanistic Biology: Aids in elucidating signaling pathways downstream of Aurora kinases and their interaction with other critical oncogenic targets.

Basic Information

Product Name	Aurora Kinase Inhibitor II
CAS No.	331770-21-9
Molecular Formula	C₂₁H₂₀FN₅O₂
Molecular Weight	393.42 g/mol
Synonyms	ZM 447439; ZM-447439; 4-(4'-Benzamidoanilino)-6,7-dimethoxyquinazoline; N-[4-[6,7-Dimethoxy-4-quinazolinyl]amino]phenyl]benzamide; Aurora Kinase Inhibitor ZM 447439; Aurora A/B Kinase Inhibitor; AZD-1152 HQPA (related analog, often searched)
EINECS	Contact for details

Quality Control

Our Aurora Kinase Inhibitor II is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications. We support our clients with full documentation for their regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep the primary container in a sealed secondary container with a desiccant. Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.