Description

Indirubin-3'-Monoxime-5-Sulphonic Acid is a chemically modified derivative of indirubin, a natural compound with significant biological activity. This water-soluble sulphonic acid derivative is engineered to enhance bioavailability and stability for advanced research and development applications. It is primarily utilized by pharmaceutical researchers, biochemists, and material scientists working in drug discovery, biochemical pathway analysis, and the development of specialized dyes or sensors.

Application

• Pharmaceutical Research & Drug Discovery: Serves as a key intermediate or reference standard in the development of kinase inhibitors, particularly targeting glycogen synthase kinase-3β (GSK-3β) and cyclin-dependent kinases (CDKs).
• Biochemical Studies: Used as a potent and selective tool compound in cell biology to study cell cycle regulation, apoptosis, and inflammatory signaling pathways.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation in pharmaceutical analysis.
• Chemical Synthesis: Acts as a versatile building block for the synthesis of more complex indirubin-based analogs with tailored properties.
• Material Science: Investigated for potential use in the development of organic semiconductors or functional dyes due to its conjugated molecular structure.

Basic Information

Product Name	Indirubin-3'-Monoxime-5-Sulphonic Acid
CAS No.	331467-05-1
Molecular Formula	C16H11N3O5S
Molecular Weight	357.34 g/mol
Synonyms	5-Sulfoindirubin-3'-monoxime; Indirubin-3'-oxime-5-sulfonic acid; 1H-Indole-3-acetic acid, 2,3-dihydro-2-oxo-α-(hydroxyimino)-5-sulfo-; 6-Sulfoindirubin-3'-monoxime (common numbering variant); GSK-3β Inhibitor IX; 5-Sulfoindirubin 3'-monoxime; Indirubin derivative 5-sulfonic acid monoxime; 2-(3'-Hydroxyimino-2-oxoindolin-5-yl)sulfonic acid
EINECS	Contact for details

Quality Control

Our Indirubin-3'-Monoxime-5-Sulphonic Acid is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurities is provided with every shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	Orange to reddish-brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Solubility	Soluble in water, DMSO; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.