Description

5-Iodoindirubin-3'-Monoxime is a potent and selective small molecule inhibitor of glycogen synthase kinase-3β (GSK-3β). This compound is a chemically modified derivative of indirubin, designed to enhance its biological activity and specificity. It serves as a critical research tool in biochemical and pharmacological studies, particularly in the fields of neuroscience, oncology, and stem cell research. Researchers in pharmaceutical development and academic institutions utilize this high-purity compound to investigate signaling pathways related to cell proliferation, differentiation, and apoptosis.

Application

• Biochemical Research: As a selective GSK-3β inhibitor for studying Wnt/β-catenin signaling pathways and their role in development and disease.
• Neuroscience Studies: Investigation of neuroprotective effects, tau protein phosphorylation, and potential therapeutic avenues for neurodegenerative disorders like Alzheimer's disease.
• Oncology Research: Exploration of its effects on cancer cell cycle arrest, apoptosis, and as a potential lead compound in anti-cancer drug discovery.
• Stem Cell Research: Used to modulate signaling pathways that control embryonic stem cell self-renewal and differentiation.
• Pharmacology: Serves as a reference standard and active pharmaceutical ingredient (API) intermediate in pre-clinical development.
• Cell Biology: Tool compound for in vitro assays to understand the role of GSK-3 in metabolism, inflammation, and mood disorders.

Basic Information

Product Name	5-Iodoindirubin-3'-Monoxime
CAS No.	331467-03-9
Molecular Formula	C16H10IN3O2
Molecular Weight	427.17 g/mol
Synonyms	5-Iodoindirubin-3'-oxime; 6'-Iodoindirubin-3'-monoxime; GSK-3β Inhibitor IX; BIO-2; 5-Iodo-1H,1'H-[2,3'-biindole]-2',3(2H)-dione 3'-oxime; 5-Iodoindirubin 3'-monoxime; I5IM; 5-Iodo-IBMN
EINECS	Contact for details

Quality Control

Our 5-Iodoindirubin-3'-Monoxime is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, and specifications can be tailored to meet specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation. Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.