Description

5-Trans Prostaglandin F2α (Tromethamine Salt) is a high-purity, synthetic prostaglandin analog used as a critical reference standard and active pharmaceutical ingredient (API) intermediate. This compound is essential for research and development in ocular therapeutics, particularly for regulating intraocular pressure. It is primarily utilized by pharmaceutical manufacturers, advanced research institutions, and analytical laboratories requiring precise and reliable bioactive compounds.

Application

• Pharmaceutical API Intermediate: Key synthetic precursor in the manufacture of prostaglandin-based ophthalmic solutions for glaucoma treatment.
• Analytical Reference Standard: Used for method development, validation, and quality control (QC) testing in HPLC, LC-MS, and other analytical techniques.
• Biomedical Research: Investigated in studies related to smooth muscle contraction, inflammation pathways, and receptor binding assays.
• Ophthalmic Drug Development: Serves as a critical material for formulating and testing next-generation intraocular pressure-lowering medications.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes and scaling production processes under cGMP conditions.

Basic Information

Product Name	5-Trans Prostaglandin F2α (Tromethamine Salt)
CAS No.	330796-56-0
Molecular Formula	C₂₃H₃₉NO₈
Molecular Weight	457.56 g/mol
Synonyms	5-trans-PGF2α tromethamine salt; Travoprost Impurity C (Tromethamine Salt); (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5-Heptenoic Acid Compound with 2-Amino-2-(hydroxymethyl)-1,3-propanediol (1:1); 5-trans-Travoprost Tromethamine; 5-trans Isomer of Travoprost Tromethamine; AL-6221 (5-trans isomer salt); Prostaglandin F2α analog (5-trans, tromethamine salt)
EINECS	Contact for details

Quality Control

Our 5-Trans Prostaglandin F2α (Tromethamine Salt) is manufactured under strict quality systems. Each batch is subjected to comprehensive analytical testing, including chiral purity and isomer content analysis, to ensure it meets stringent specifications for pharmaceutical development. Certificates of Analysis (COA) with full traceability are provided and can be tailored to meet specific pharmacopeial (e.g., USP) or internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or refrigerated (2-8°C) as specified. The product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Isomeric Purity (5-trans)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.