Description

Sirt2 Inhibitor Ii, Ak-1 is a potent and selective small molecule inhibitor of the Sirtuin 2 (Sirt2) deacetylase enzyme. This compound is a critical research tool for investigating the role of Sirt2 in cellular processes such as aging, metabolism, and neurodegeneration. It is primarily utilized by academic, pharmaceutical, and biotechnology researchers in the fields of life science research, drug discovery, and target validation.

Application

• Biochemical Research: Used as a selective probe to study Sirt2 deacetylase activity and its inhibition kinetics in in vitro assays.
• Cell Biology Studies: Applied in cell-based models to investigate the functional consequences of Sirt2 inhibition on pathways related to aging, stress response, and cell cycle regulation.
• Neurodegenerative Disease Research: A key compound for exploring the therapeutic potential of Sirt2 inhibition in models of Parkinson's disease, Huntington's disease, and other neurodegenerative conditions.
• Oncology Research: Employed to examine the role of Sirt2 in tumorigenesis, cancer cell metabolism, and as a potential target for anticancer drug development.
• Metabolic Disorder Studies: Utilized in research focused on the connection between Sirt2, insulin signaling, and metabolic syndromes.
• Drug Discovery & High-Throughput Screening (HTS): Serves as a reference standard and positive control in screening campaigns to identify novel Sirt2 modulators.

Basic Information

Product Name	Sirt2 Inhibitor Ii, Ak-1
CAS No.	330461-64-8
Molecular Formula	C17H14N4O2S
Molecular Weight	338.38 g/mol
Synonyms	AK-1; Sirt2 Inhibitor II; 3-(1-azepanylsulfonyl)-N-(3-bromophenyl)benzamide; SirReal2; Sirtuin 2 Inhibitor AK-1; (3-azepan-1-ylsulfonyl-N-(3-bromophenyl)benzamide); AG-690/15756041; BDBM50102657.
EINECS	Contact for details

Quality Control

Our Sirt2 Inhibitor Ii, Ak-1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and identity verification. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.