Description

Hif-1Alpha/2Alpha Inhibitor CAS NO 329932-55-0 is a potent, small-molecule inhibitor targeting the Hypoxia-Inducible Factor (HIF) signaling pathway. This compound is crucial for research and development in oncology and other fields where hypoxia-mediated gene expression plays a key pathological role. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel therapeutics for cancer, ischemic diseases, and other conditions linked to HIF activity.

Application

• Biomedical Research: A critical tool for studying the molecular mechanisms of hypoxia and angiogenesis in cellular and animal models.
• Oncology Drug Discovery: Used as a reference compound or lead molecule in the development of novel anti-cancer therapies targeting tumor hypoxia and metastasis.
• Ischemic Disease Research: Investigated for its potential therapeutic effects in conditions like myocardial infarction and stroke by modulating HIF-mediated responses.
• Biochemical Assay Development: Serves as a standard or control in high-throughput screening (HTS) campaigns to identify new HIF pathway modulators.
• Preclinical Studies: Employed in pharmacokinetic (PK), pharmacodynamic (PD), and toxicology studies to evaluate the efficacy and safety profile of HIF-targeting agents.
• Signal Pathway Analysis: Essential for dissecting cross-talk between the HIF pathway and other critical cellular signaling networks.

Basic Information

Product Name	Hif-1Alpha/2Alpha Inhibitor
CAS No.	329932-55-0
Molecular Formula	C₁₉H₁₄N₄O₂
Molecular Weight	330.34 g/mol
Synonyms	HIF-1 Inhibitor, HIF-1α Inhibitor, HIF-2α Inhibitor, 2-(4-[(2-Pyridinylmethyl)sulfonyl]phenyl)-1H-benzimidazole, PX-478, PX478, NSC 724998, CHEMBL456980, BDBM50389375
EINECS	Contact for details

Quality Control

Our Hif-1Alpha/2Alpha Inhibitor is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or with desiccant to maintain stability and purity. Allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.