Description

Monastrol is a potent and selective small molecule inhibitor of the mitotic kinesin Eg5 (KSP), a key protein involved in spindle formation during cell division. This targeted mechanism makes it a valuable chemical tool for disrupting mitosis and inducing cell cycle arrest, primarily in cancer research. It is essential for researchers and pharmaceutical developers in the fields of oncology, cell biology, and drug discovery who require high-purity biochemicals for target validation and screening assays.

Application

• Biochemical Research: A critical tool compound for studying mitotic mechanisms, spindle assembly, and kinesin motor protein function.
• Anticancer Drug Discovery: Used in high-throughput screening (HTS) and target validation for developing novel anti-mitotic cancer therapeutics.
• Cell Biology Studies: Induces monopolar spindles and mitotic arrest in cell cultures, enabling research into cell cycle checkpoints and apoptosis.
• Academic & Pharmaceutical R&D: Serves as a reference standard and positive control in experiments targeting the Eg5/KSP pathway.
• Chemical Probe Development: Used as a scaffold or lead compound for the synthesis and optimization of more potent Eg5 inhibitors.

Basic Information

Product Name	Monastrol
CAS No.	329689-23-8
Molecular Formula	C14H14N2O3S
Molecular Weight	290.34 g/mol
Synonyms	Monastrol; 3,4-Dihydro-4-(3-hydroxyphenyl)-2(1H)-thioxo-6-methylpyrimidin-5-carboxylic acid ethyl ester; Ethyl 4-(3-hydroxyphenyl)-6-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate; Eg5 Inhibitor I; KSP Inhibitor; Kinesin Spindle Protein Inhibitor
EINECS	Contact for details

Quality Control

Our Monastrol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards for research chemicals, ensuring reliable performance in sensitive biological assays.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.