Description

1-Bromodifluoromethyl-Imidazole is a versatile and highly reactive organofluorine building block. This compound is valued for its ability to introduce the difluoromethyl group, a key motif in modern medicinal chemistry and agrochemical design. It is primarily sought after by research scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for introducing the difluoromethyl group into drug candidates, particularly in the development of kinase inhibitors, antiviral agents, and anti-inflammatory compounds.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and pesticides where the difluoromethyl moiety enhances biological activity and metabolic stability.
• Material Science: Serves as a precursor for synthesizing specialty polymers, liquid crystals, and organic electronic materials requiring specific fluorine-based functionalities.
• Cross-Coupling Reactions: Acts as an effective electrophile in various metal-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to construct complex fluorinated aromatic and heteroaromatic systems.
• Fluorine-18 Radiochemistry: Potential use as a precursor or labeling agent in the synthesis of Positron Emission Tomography (PET) tracers for medical imaging.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes and molecular tags to study enzyme function and biological pathways.

Basic Information

Product Name	1-Bromodifluoromethyl-Imidazole
CAS No.	328406-16-2
Molecular Formula	C4H3BrF2N2
Molecular Weight	196.98 g/mol
Synonyms	1-(Bromodifluoromethyl)-1H-imidazole; 1H-Imidazole, 1-(bromodifluoromethyl)-; Imidazole, 1-(bromodifluoromethyl)-; 1-Bromo-2,2-difluoro-2-(1H-imidazol-1-yl)ethane; Bromodifluoromethylimidazole; 1-(Bromodifluoromethyl)imidazole
EINECS	Contact for details

Quality Control

Our 1-Bromodifluoromethyl-Imidazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.