Description

Defluoro Paroxetine, Hydrochloride is a key pharmaceutical intermediate and reference standard in the synthesis of active pharmaceutical ingredients (APIs). This compound is of significant importance for research and development, particularly in the study of serotonin reuptake inhibitors and the creation of novel therapeutic analogs. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in drug discovery, process development, and quality control.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis and research of paroxetine analogs and related central nervous system (CNS) active compounds.
• Reference Standard: Used for analytical method development, validation, and quality control testing in pharmaceutical manufacturing to ensure product identity and purity.
• Research & Development: Serves as a precursor in medicinal chemistry for the design and study of new chemical entities targeting serotonin transporters.
• Process Chemistry: Employed in scaling up and optimizing synthetic routes for API production under Good Manufacturing Practice (GMP) conditions.
• Impurity Profiling: Used as a marker or standard to identify and quantify related substances and degradation products in final drug substances.

Basic Information

Item	Detail
Product Name	Defluoro Paroxetine, Hydrochloride
CAS No.	324024-00-2
Molecular Formula	C19H21NO3·HCl
Molecular Weight	347.83 g/mol (as hydrochloride salt)
Synonyms	(-)-trans-4-(4'-Fluorophenyl)-3-[(3',4'-methylenedioxy)phenoxy]methylpiperidine Hydrochloride (Defluoro analog); Paroxetine Defluoro Impurity Hydrochloride; Paroxetine Related Compound; 3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine Hydrochloride (Defluoro); FC-1111 (Defluoro analog); BRL-29060 (Defluoro analog); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Defluoro Paroxetine, Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identification by spectroscopic methods (IR, NMR), and residual solvent analysis to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) documenting all test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.