Description

Gak Inhibitor 49 is a potent and selective small molecule inhibitor of the G protein-coupled receptor kinase 2 (GRK2), also known as β-adrenergic receptor kinase 1 (βARK1). This compound is a critical research tool for investigating cellular signaling pathways related to cardiovascular function, heart failure, and GPCR desensitization. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in drug discovery and basic biochemical research.

Application

• Biochemical Research: A key reagent for studying GRK2-mediated phosphorylation and desensitization of G protein-coupled receptors (GPCRs).
• Cardiovascular Disease Models: Used in preclinical research to investigate the role of GRK2 in heart failure, hypertrophy, and myocardial ischemia.
• Signal Transduction Studies: Essential for elucidating downstream effects of β-adrenergic receptor signaling and other GPCR pathways in cellular assays.
• Drug Discovery Screening: Serves as a reference compound and positive control in high-throughput screening campaigns targeting GRK2 for therapeutic intervention.
• Academic & Institutional Research: Supports fundamental research in molecular biology, pharmacology, and cellular physiology.

Basic Information

Product Name	Gak Inhibitor 49
CAS No.	319492-82-5
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	βARK1 Inhibitor; GRK2 Inhibitor; 6-[4-(2-{4-[(2,4-Dichlorophenyl)methyl]piperazin-1-yl}ethoxy)phenyl]-3-methyl-1,2,4-triazolo[3,4-a]phthalazine; GAK Inhibitor 49; GAK-Inh 49; CAS 319492-82-5
EINECS	Contact for details

Quality Control

Our Gak Inhibitor 49 is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by comprehensive analytical documentation. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.