Description

Ptc-209 (Ptc209 CAS NO 315704-66-6) is a potent and selective small molecule inhibitor of the Hedgehog signaling pathway. This compound is critical for researchers and developers targeting aberrant Hedgehog pathway activity, which is implicated in various cancers and developmental disorders. It is an essential tool for pharmaceutical R&D, oncology research, and high-throughput screening applications in the life sciences sector.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel cancer therapeutics.
• Oncology Studies: Used in in vitro and in vivo research to investigate the role of Hedgehog signaling in tumorigenesis, metastasis, and cancer stem cell maintenance.
• Biochemical Pathway Analysis: A vital reagent for selectively inhibiting the Hedgehog pathway to study its function in cell differentiation, proliferation, and tissue patterning.
• High-Throughput Screening (HTS): Employed in drug discovery campaigns to identify and validate new compounds targeting similar signaling pathways.
• Academic & Contract Research: Essential for universities and CROs conducting fundamental research on developmental biology and molecular oncology.

Basic Information

Product Name	Ptc-209
CAS No.	315704-66-6
Molecular Formula	C23H21N3O3S
Molecular Weight	419.50 g/mol
Synonyms	PTC-209; PTC209; 2-(4-Chlorophenyl)-N-[(1S)-1-(4-fluorophenyl)ethyl]-1,3-thiazole-5-carboxamide; Hedgehog Pathway Inhibitor PTC-209; BMI1 Inhibitor PTC-209; Bmi-1 Inhibitor PTC-209; 5-Thiazolecarboxamide, 2-(4-chlorophenyl)-N-[(1S)-1-(4-fluorophenyl)ethyl]-; (S)-N-(1-(4-Fluorophenyl)ethyl)-2-(4-chlorophenyl)thiazole-5-carboxamide
EINECS	Contact for details

Quality Control

Our Ptc-209 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurities is provided with every shipment to ensure compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.