Description

4',5,7-Trihydroxyisoflavone-2',6'-D2 is a deuterium-labeled analog of the natural isoflavone genistein, a compound of significant interest in biochemical and pharmaceutical research. This stable isotope-labeled compound is essential for use as an internal standard in mass spectrometry-based analytical methods, ensuring precise quantification and reliable metabolic studies. It is primarily utilized by research institutions, pharmaceutical developers, and analytical laboratories focused on pharmacokinetics, biomarker discovery, and the investigation of phytoestrogen pathways.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of genistein and its metabolites in complex biological matrices like plasma, serum, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables tracing and detailed analysis of absorption, distribution, metabolism, and excretion (ADME) profiles.
• Biomedical Research: Used in studies investigating the role of isoflavones in hormonal regulation, cancer research, and cardiovascular health.
• Analytical Method Development and Validation: Serves as a reference standard to establish specificity, accuracy, and precision in new assay protocols.
• Nutraceutical and Phytoestrogen Research: Supports quality control and efficacy studies in the development of soy-based and other botanical supplements.

Basic Information

Product Name	4',5,7-Trihydroxyisoflavone-2',6'-D2
CAS No.	315204-48-9
Molecular Formula	C15H8D2O5
Molecular Weight	272.26 g/mol
Synonyms	Genistein-2',6'-D2; 5,7-Dihydroxy-3-(2,6-dideuterio-4-hydroxyphenyl)-4H-1-benzopyran-4-one; 4',5,7-Trihydroxyisoflavone-d2; Deuterated Genistein; Isoflavone D2; 315204-48-9; Stable Isotope Labeled Genistein
EINECS	Contact for details

Quality Control

Every batch of 4',5,7-Trihydroxyisoflavone-2',6'-D2 is produced and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity, verified by advanced spectroscopic and chromatographic techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and analytical results is provided with each shipment to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light). For long-term storage, consider storing desiccated under inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.