Description

Ucf-101 CAS NO 313649-08-0 is a potent and selective small-molecule inhibitor of the apoptosis regulator protein, C/EBP homologous protein (CHOP). This compound is a critical research tool for investigating the unfolded protein response (UPR) and endoplasmic reticulum (ER) stress pathways in cellular models. It is primarily utilized by researchers and scientists in the fields of biochemistry, molecular biology, and pharmacology for target validation and mechanistic studies. Ucf-101 enables precise modulation of stress-induced apoptosis, supporting advanced drug discovery and disease research.

Application

• Biochemical Research: A key reagent for studying the molecular mechanisms of ER stress and the UPR pathway.
• Cell Biology Studies: Used to inhibit CHOP-mediated apoptosis in various cell lines to understand cell survival and death signaling.
• Drug Discovery & Target Validation: Serves as a pharmacological probe to validate CHOP as a therapeutic target in diseases like neurodegeneration, diabetes, and ischemia-reperfusion injury.
• Academic & Institutional Research: Essential for universities and research institutes conducting fundamental research on cellular stress responses.
• Pharmaceutical R&D: Supports preclinical research for developing novel therapeutics targeting apoptosis-related disorders.

Basic Information

Product Name	Ucf-101
CAS No.	313649-08-0
Molecular Formula	C₁₉H₁₅N₅O₂
Molecular Weight	345.36 g/mol
Synonyms	UCF-101; UCF101; 3-Phenyl-5-(2,4,6-trimethoxyphenyl)-1H-pyrazole; CHOP Inhibitor Ucf-101; Apoptosis Inhibitor Ucf-101; C/EBP Homologous Protein Inhibitor; ER Stress Inhibitor Ucf-101; 5-(2,4,6-Trimethoxyphenyl)-3-phenyl-1H-pyrazole
EINECS	Contact for details

Quality Control

Our Ucf-101 is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. A detailed Certificate of Analysis (COA) containing purity, identity, and impurity profiles is provided with every shipment to support your research integrity and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. For long-term storage, keep desiccated under inert atmosphere. Allow the product to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.