Description

Zosuquidar Monohydrate is a potent and selective third-generation P-glycoprotein (P-gp) inhibitor, widely recognized for its role in overcoming multidrug resistance (MDR) in cancer therapy. Its primary value lies in its ability to enhance the intracellular accumulation and efficacy of co-administered chemotherapeutic agents, thereby restoring treatment sensitivity. This compound is essential for pharmaceutical R&D, particularly in oncology research, preclinical studies, and the development of novel drug delivery systems targeting resistant cancers.

Application

• Oncology Research: Used as a key pharmacological tool to study and reverse P-gp-mediated multidrug resistance in various cancer cell lines and animal models.
• Drug Discovery & Development: Employed in preclinical studies to evaluate the efficacy of new chemotherapeutic agents when combined with P-gp inhibition.
• Pharmacokinetic Studies: Investigates the role of P-gp in drug absorption, distribution, metabolism, and excretion (ADME).
• Formulation Development: Aids in the design of advanced drug delivery systems aimed at bypassing efflux pump mechanisms.
• Biochemical Assays: Serves as a reference standard in in vitro assays to characterize P-gp inhibitor activity and specificity.
• Academic Research: Utilized in university and institutional labs for fundamental research on membrane transporters and cancer biology.

Basic Information

Product Name	Zosuquidar Monohydrate
CAS No.	312905-17-2
Molecular Formula	C32H31F2N3O2 • H2O
Molecular Weight	545.62 g/mol (Monohydrate)
Synonyms	LY335979 Monohydrate; Zosuquidar Trihydrochloride (base form); (R)-N-(Quinolin-6-yl)-2-(2-(4-(3,4-difluorobenzoyl)piperazin-1-yl)acetamido)-3-phenylpropanamide Monohydrate; LY-335979; P-gp Inhibitor LY335979; Multidrug Resistance Reversal Agent LY335979; NSC 710464
EINECS	Contact for details

Quality Control

Our Zosuquidar Monohydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	3.0% - 5.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.