Description

6-Methoxy-Pyridine-3-Sulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative used as a key building block in advanced organic synthesis. This compound is valued for its role in introducing the 6-methoxypyridine-3-sulfonyl moiety, a versatile functional group in medicinal chemistry and material science. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its sulfonamide-forming capability.
• Chemical Biology & Proteomics: Serves as a reactive handle for labeling, cross-linking, or modifying biomolecules in research applications.
• Material Science: Employed in the creation of specialty polymers, liquid crystals, and organic electronic materials where the pyridine-sulfonyl unit imparts specific electronic or structural properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for custom synthesis projects and library generation.

Basic Information

Product Name	6-Methoxy-Pyridine-3-Sulfonyl Chloride
CAS No.	312300-42-8
Molecular Formula	C6H6ClNO3S
Molecular Weight	207.64 g/mol
Synonyms	3-Chlorosulfonyl-6-methoxypyridine; 6-Methoxy-3-pyridinesulfonyl chloride; 6-Methoxypyridine-3-sulfonyl chloride; 6-Methoxy-pyridine-3-sulfonyl chloride; 6-Methoxynicotinic sulfonyl chloride; 3-Pyridinesulfonyl chloride, 6-methoxy-; 312300-42-8
EINECS	Contact for details

Quality Control

Our production of 6-Methoxy-Pyridine-3-Sulfonyl Chloride adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for your synthetic processes. Each lot is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.