Description

Tubulysin D is a highly potent cytotoxic peptide isolated from myxobacteria, representing a significant compound in advanced pharmaceutical research. Its primary value lies in its exceptional anti-mitotic activity, which disrupts microtubule dynamics and induces apoptosis in cancer cells. This makes it a critical reference standard and a promising lead compound for researchers and developers in the fields of oncology drug discovery, bio-conjugation, and targeted cancer therapy development.

Application

• Anticancer Drug Discovery & Development: Serves as a potent reference standard and lead molecule for designing novel chemotherapeutic agents and antibody-drug conjugates (ADCs).
• Biomedical Research: Used in in vitro and in vivo studies to investigate mechanisms of microtubule inhibition, cell cycle arrest, and apoptosis.
• Pharmacology & Toxicology Studies: Employed to establish dose-response relationships, evaluate therapeutic windows, and study resistance mechanisms in various cancer cell lines.
• Chemical Biology & Proteomics: Utilized as a molecular tool to probe tubulin dynamics and interactions within the cytoskeleton.
• ADC Payload Synthesis: Acts as a high-potency warhead for the synthesis and evaluation of next-generation antibody-drug conjugates.
• Analytical Reference Standard: Provides a certified benchmark for the identification, purity assessment, and quantification of Tubulysin analogs in quality control and method development.

Basic Information

Product Name	Tubulysin D
CAS No.	309935-57-7
Molecular Formula	C₄₃H₆₅N₅O₁₀
Molecular Weight	812.0 g/mol
Synonyms	Tubulysin D; Tubugis D; (3S,6S,9S,12S,15S,18S,21S,24S,27S,30S,33S)-33-[(2S)-2-[(2S)-2-Acetamido-3-methylbutanamido]-3-methylbutanamido]-9,12,15,18,21,24,27,30-octahydroxy-3,6-di(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaoxo-1λ⁵,4λ⁵,7λ⁵,10λ⁵,13λ⁵,16λ⁵,19λ⁵,22λ⁵,25λ⁵,28λ⁵,31λ⁵-dodecaazacyclotritriacontan-32-yl (2R)-2-amino-3-methylbutanoate; Antibiotic IA 0912D
EINECS	Contact for details

Quality Control

Our Tubulysin D is manufactured under strict quality management systems to ensure the highest standards of purity and consistency for research applications. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, MS for identity confirmation, and NMR for structural verification. A detailed Certificate of Analysis (COA) is provided, documenting the exact specifications and test results. We adhere to cGMP guidelines where applicable to support preclinical and development-phase requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to minimize condensation and exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular mass
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.